McDonald rode the triple Group One winner when he was successful in last month's Show County Quality with Hugh Bowman his rider when he was unplaced in the Tramway Stakes.
Bowman will be on champion Winx as she attempts to stretch her winning sequence to 27 and her Group One tally to 20.
“I wouldn't run him in the Cameron with 63kg, and even though we might be racing for second behind Winx, the Optic White looks the logical race for him,” Lees said.
“This is the first time he has run at 1600 metres in 12 months when he finished down the course behind Humidor in the Makybe Diva Stakes at Flemington last September.
“As we subsequently found out when we brought him back home, he wasn't right and had to undergo colic surgery.”
Lees said Le Romain's performance on Saturday would help determine whether he aimed him at the Epsom Handicap.
Le Romain was given 61kg in the Bill Ritchie.
Lees will have two runners in the Cameron, Group One winners Sense Of Occasion who has 60kg and Prized Icon who carries 57.5kg.
“Tommy Berry will ride Prized Icon and I haven't booked a jockey yet for Sense Of Occasion,” Lees said.
“Sense Of Occasion is coming back from a tendon injury and we have taken him along steadily. It's one race at a time.”
Both are also entered for the Epsom with Sense Of Occasion given 55kg and Prized Icon 52.5kg.
Winx is at $1.15 to win her third George Main Stakes with Le Romain at $15 alongside Tramway winner Comin' Through ahead of Wednesday's acceptances.